Frequently Asked Questions

If you have a question about alli, check here first to see if we’ve answered it already. If the information you need isn’t here, please contact us or talk to your pharmacist or doctor. You should also read the information contained within the alli pack before you start taking alli.

GSK update

In light of recent media reports regarding the Food and Drug Administration (FDA) review of orlistat (alli) in relation to liver injury please find below a statement from GlaxoSmithKline.

"There is no evidence that alli causes liver injury.

alli is a ‘non-systemically’ acting medicine – it is minimally absorbed in the blood and works locally in the gastro-intestinal tract. There is therefore no obvious biological mechanism to suggest liver injury can occur with alli. The safety of consumers is of utmost importance to GSK. We continually monitor and evaluate reports of adverse effects associated with use of all of our products, including alli.

Orlistat, the active ingredient in alli, is the most-studied weight loss medicine, with safety established through 100 clinical studies involving more than 30 thousand patients. GSK regularly communicates with independent regulatory bodies and provides them with comprehensive safety data on our products. Any routine assessment from a regulatory body does not mean that a risk or causal relationship exists. "

GSK also wants to reiterate a key point from the FDA statement below:

FDA statement:
The FDA’s analysis of these data is ongoing, and no definite association between liver injury and orlistat has been established at this time. Consumers taking Xenical should continue to take it as prescribed, and those using over-the-counter alli should continue to use the product as directed.

Contact Us
If you have any further queries please contact our Customer Relations team.